Pub. Date : 1996 Mar
PMID : 8769893
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Carbachol treatment increased the levels of intracellular Ca2+ and inositol 1,4,5-trisphosphate (IP3) and enhanced transcription of the TH gene. | Carbachol | tyrosine hydroxylase | Rattus norvegicus |
| 2 | The muscarinic receptor antagonist atropine completely abolished the carbachol effect on TH gene expression. | Carbachol | tyrosine hydroxylase | Rattus norvegicus |
| 3 | Transient transfection analysis of the 5" upstream region of TH gene revealed that the AP1 cis-acting element at -205 to -199 bp was responsible for carbachol stimulation. | Carbachol | tyrosine hydroxylase | Rattus norvegicus |
| 4 | Thus, Ca(2+)-independent PKC may play a role in carbachol-induced TH gene expression. | Carbachol | tyrosine hydroxylase | Rattus norvegicus |