Title : Distinct mechanisms mediate SHC association with the activated and resting B cell antigen receptor.

Pub. Date : 1996 Aug

PMID : 8765045






3 Functional Relationships(s)
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1 The results reported here indicate that the resting, nonphosphorylated BCR associates with the Grb-2/Sos-linker SHC via the Ig-alpha immunoreceptor-based tyrosine activation motif (ITAM). Tyrosine xylosyltransferase 2 Homo sapiens
2 In view of previous studies which demonstrated p21ras co-capping with ligated BCR, the data presented here suggest that Ig-alpha/beta- and SHC tyrosine phosphorylation-dependent recruitment of the Grb2/Sos complex to the receptor can occur and may provide a mechanism by which the nucleotide exchange activity of Sos could mediate activation of BCR-localized p21ras. Tyrosine xylosyltransferase 2 Homo sapiens
3 In view of previous studies which demonstrated p21ras co-capping with ligated BCR, the data presented here suggest that Ig-alpha/beta- and SHC tyrosine phosphorylation-dependent recruitment of the Grb2/Sos complex to the receptor can occur and may provide a mechanism by which the nucleotide exchange activity of Sos could mediate activation of BCR-localized p21ras. Tyrosine xylosyltransferase 2 Homo sapiens