Protein Name xylosyltransferase 2
Organism Homo sapiens
Gene ID 64132
Gene Symbol

XYLT2

UniProt Q9H1B5 (XYLT2_HUMAN), B4DT06 (B4DT06_HUMAN)
Relationships Total Number of functionally related compound(s) : 136
Total Number of Articles : 119
Description

xylosyltransferase 2

Gene Summary

The protein encoded by this gene is an isoform of xylosyltransferase, which belongs to a family of glycosyltransferases. This enzyme transfers xylose from UDP-xylose to specific serine residues of the core protein and initiates the biosynthesis of glycosaminoglycan chains in proteoglycans including chondroitin sulfate, heparan sulfate, heparin and dermatan sulfate. The enzyme activity, which is increased in scleroderma patients, is a diagnostic marker for the determination of sclerotic activity in systemic sclerosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

synonyms
  • xylosyltransferase 2
  • UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase
  • peptide O-xylosyltransferase 1
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Properties