Title : Differential regulation of cell cycle machinery by various antiproliferative agents is linked to macrophage arrest at distinct G1 checkpoints.

Pub. Date : 1996 Aug 1

PMID : 8760301






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We report that 8-bromo-cAMP (8Br-cAMP) and lipopolysaccharide (LPS) potently reduced CSF-1-stimulated cyclin D1 protein, and cyclin-dependent kinase (cdk) 4 mRNA and protein levels, while the inhibitory effects of the Na+/ H+ antiport inhibitor 5-(N",N"-dimethyl) amiloride (DMA) and interferon gamma (IFN gamma ) were only weak. 8-Bromo Cyclic Adenosine Monophosphate colony stimulating factor 1 Homo sapiens
2 We report that 8-bromo-cAMP (8Br-cAMP) and lipopolysaccharide (LPS) potently reduced CSF-1-stimulated cyclin D1 protein, and cyclin-dependent kinase (cdk) 4 mRNA and protein levels, while the inhibitory effects of the Na+/ H+ antiport inhibitor 5-(N",N"-dimethyl) amiloride (DMA) and interferon gamma (IFN gamma ) were only weak. 8-Bromo Cyclic Adenosine Monophosphate colony stimulating factor 1 Homo sapiens
3 Furthermore, 8Br-cAMP and to a lesser extent IFN gamma, also reduced CSF-1-stimulated levels of E2F DNA binding activity in a macrophage cell line, BAC1.2F5. 8-Bromo Cyclic Adenosine Monophosphate colony stimulating factor 1 Homo sapiens