Title : Somatically mutated B cell pool provides precursors for insulin antibodies.

Pub. Date : 1996 Jul 15

PMID : 8752927






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Engineered mAb constructs that express germ-line or mutated V(H) genes show that somatic mutations introducing aspartic acid in or adjacent to CDRH2 play a key role in insulin binding. Aspartic Acid insulin Homo sapiens