Title : Crystallographic determination of the structures of human alpha-thrombin complexed with BMS-186282 and BMS-189090.

Pub. Date : 1996 Feb

PMID : 8745399






1 Functional Relationships(s)
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1 Although PPACK forms covalent bonds to both serine and the histidine of the catalytic triad of thrombin, neither BMS-186282 nor BMS-189090 bind covalently and only BMS-186282 forms a hydrogen bond to the serine of the catalytic triad. Histidine coagulation factor II, thrombin Homo sapiens