Title : Inhibition of inducible nitric oxide synthase expression by novel nonsteroidal anti-inflammatory derivatives with gastrointestinal-sparing properties.

Pub. Date : 1996 Apr

PMID : 8730734






4 Functional Relationships(s)
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1 LPS-induced nitrite production was markedly attenuated by the nitroxybutylester derivatives of flurbiprofen (FNBE), aspirin, ketoprofen, naproxen, diclofenac and ketorolac, with each compound reducing accumulated nitrite levels by > 40% at the maximum concentrations (100 micrograms ml-1) used. Nitrites toll-like receptor 4 Mus musculus
2 LPS-induced nitrite production was markedly attenuated by the nitroxybutylester derivatives of flurbiprofen (FNBE), aspirin, ketoprofen, naproxen, diclofenac and ketorolac, with each compound reducing accumulated nitrite levels by > 40% at the maximum concentrations (100 micrograms ml-1) used. Nitrites toll-like receptor 4 Mus musculus
3 Further examination revealed that nitrite production was inhibited in a concentration-dependent (1-100 micrograms ml-1) manner by FNBE which at 100 micrograms ml-1 decreased LPS-stimulated levels by 63.3 +/- 8.6% (n = 7). Nitrites toll-like receptor 4 Mus musculus
4 FNBE reduced LPS-induced nitrite production when added to cells up to 4 h after LPS. Nitrites toll-like receptor 4 Mus musculus