| Protein Name | toll-like receptor 4 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 21898 |
| Gene Symbol | Tlr4 |
| UniProt | Q9QUK6 (TLR4_MOUSE), L0CL36 (L0CL36_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
2266
Total Number of Articles : 4041 |
Description |
toll-like receptor 4 |
| Gene Summary |
This gene belongs to the evolutionarily-conserved Toll-like receptor family, whose members are type-1 transmembrane proteins that are involved in innate immunity. Toll-like receptors are characterized by an extracellular leucine-rich repeat domain that functions in ligand recognition and an intracellular toll/interleukin-1 receptor-like domain that is crucial for signal transduction. The receptor encoded by this gene mediates the innate immune response to bacterial lipopolysaccharide, a major component of the outer membrane of Gram-negative bacteria, through synthesis of pro-inflammatory cytokines and chemokines. In addition, this protein can recognize other pathogens from Gram-negative and Gram-positive bacteria as well as viral components. Mice deficient in this gene display a number of immune response-related phenotypes including hyporesponsiveness to bacterial lipopolysaccharide and increased levels of respiratory syncytial virus compared to controls. [provided by RefSeq, Sep 2015] |
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