Pub. Date : 1996 Aug 15
PMID : 8706020
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats. | Irinotecan | glucuronidase, beta | Rattus norvegicus |
2 | Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats. | Irinotecan | glucuronidase, beta | Rattus norvegicus |
3 | Analysis of CPT-11 and its metabolites in the feces indicated that antibiotics completely inhibited the deconjugation of the glucuronic conjugate of 7-ethyl-10-hydroxycamptothecin by beta-glucuronidase. | Irinotecan | glucuronidase, beta | Rattus norvegicus |
4 | Analysis of CPT-11 and its metabolites in the feces indicated that antibiotics completely inhibited the deconjugation of the glucuronic conjugate of 7-ethyl-10-hydroxycamptothecin by beta-glucuronidase. | Irinotecan | glucuronidase, beta | Rattus norvegicus |
5 | It is suggested that CPT-11-induced diarrhea would be attributable to the damage to the cecum, and that the inhibition of the beta-glucuronidase activity in the intestinal microflora is a major protective effect of antibiotics. | Irinotecan | glucuronidase, beta | Rattus norvegicus |