Pub. Date : 1996 Feb
PMID : 8699135
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Forskolin (10 microM) markedly increased production of both androstenedione (fivefold) and progesterone (threefold) as well as the activity of 3 beta HSD (sevenfold), and P450c17 (sevenfold) over basal. | Colforsin | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 2 | Forskolin stimulated the expression of mRNA for P450scc (fourfold), 3 beta HSD (threefold), and P450c17 (eightfold) over basal. | Colforsin | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 3 | This was attributed to a reduction of P450c17 mRNA (45% of forskolin alone) and activity (45% of forskolin alone). | Colforsin | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 4 | This was attributed to a reduction of P450c17 mRNA (45% of forskolin alone) and activity (45% of forskolin alone). | Colforsin | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 5 | HOTT cell responses to activin (0.05-50 ng/ml) and inhibin (0.05-50 ng/ml) in the presence of forskolin demonstrated dose-dependent effects on the steroid accumulation, enzymatic activity and mRNA expression of P450c17. | Colforsin | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |