Pub. Date : 1996 Jul
PMID : 8694388
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The current study aimed to clarify the inhibitory mechanisms of halothane on thrombin-induced human platelet aggregation by measuring (1) platelet-surface glycoprotein Ib expression, (2) the concentration of intracellular free Ca2+ ([Ca2+]i) measured simultaneously with aggregation, (3) the concentration of intracellular inositol 1,4,5-triphosphate, and (4) the concentration of intracellular cyclic 3",5"-adenosine monophosphate ([cAMP]i). | Halothane | coagulation factor II, thrombin | Homo sapiens |
| 2 | Halothane decreased the thrombin stimulated [Ca2+]i transient and inhibited platelet aggregation in a dose-dependent manner, both in the presence and in the absence of external Ca2+. | Halothane | coagulation factor II, thrombin | Homo sapiens |
| 3 | Halothane inhibited the increase in inositol 1,4,5-triphosphate induced by thrombin. | Halothane | coagulation factor II, thrombin | Homo sapiens |
| 4 | CONCLUSIONS: Halothane inhibits thrombin-induced human platelet aggregation by decreasing [Ca2+]i without inhibiting agonist-receptor binding; the inhibitory effect of halothane on [Ca2+]i might be mediated by a decrease in inositol 1,4,5 triphosphate and in part by an increase in [cAMP]i. | Halothane | coagulation factor II, thrombin | Homo sapiens |
| 5 | CONCLUSIONS: Halothane inhibits thrombin-induced human platelet aggregation by decreasing [Ca2+]i without inhibiting agonist-receptor binding; the inhibitory effect of halothane on [Ca2+]i might be mediated by a decrease in inositol 1,4,5 triphosphate and in part by an increase in [cAMP]i. | Halothane | coagulation factor II, thrombin | Homo sapiens |