Title : ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles establishes MRP as a broad specificity transporter.

Pub. Date : 1996 Jul 9

PMID : 8692921






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The broad substrate specificity of MRP was confirmed by the observation that daunorubicin transport was competitively inhibited by reduced and oxidized glutathione, the glutathione conjugates S-(p-azidophenacyl)-glutathione (APA-SG) and S-(2,4-dinitrophenyl)glutathione (DNP-SG), arsenate, and the LTD4 antagonist MK571. Daunorubicin ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus