Title : Synthetic alleles at position 121 define a functional domain of human interleukin-1 beta.

Pub. Date : 1996 Jun 1

PMID : 8681939






2 Functional Relationships(s)
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1 The non-conservative substitution of the tyrosine residue at position 121 of human interleukin-1 beta (IL-1 beta) generates protein mutants showing strong reduction of the capacity to induce (a) prostaglandin E2 (PGE2) release from fibroblasts and smooth muscle cells, (b) murine T-cells proliferation and (c) activation of interleukin-6 (IL-6) gene expression. Dinoprostone interleukin 6 Mus musculus
2 The non-conservative substitution of the tyrosine residue at position 121 of human interleukin-1 beta (IL-1 beta) generates protein mutants showing strong reduction of the capacity to induce (a) prostaglandin E2 (PGE2) release from fibroblasts and smooth muscle cells, (b) murine T-cells proliferation and (c) activation of interleukin-6 (IL-6) gene expression. Dinoprostone interleukin 6 Mus musculus