Pub. Date : 1996 Apr
PMID : 8668925
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rapamycin was compared to cyclosporine A for its ability to inhibit P-glycoprotein on normal human peripheral blood mononuclear cells (PBMC). | Sirolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | P-glycoprotein inhibition of ex vivo lymphocytes with three multi-drug resistant T-cell lines showed susceptibility of P-glycoprotein to rapamycin dependent on the cell type. | Sirolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | P-glycoprotein inhibition of ex vivo lymphocytes with three multi-drug resistant T-cell lines showed susceptibility of P-glycoprotein to rapamycin dependent on the cell type. | Sirolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Compared to cyclosporine A, the reduced ability of rapamycin to inhibit P-glycoprotein reflects a reduced avidity in its binding to P-glycoprotein and perhaps increased access to the cell interior. | Sirolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | Compared to cyclosporine A, the reduced ability of rapamycin to inhibit P-glycoprotein reflects a reduced avidity in its binding to P-glycoprotein and perhaps increased access to the cell interior. | Sirolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | The authors speculate that interactions with P-glycoprotein may partially modulate the immunosuppressive effects of rapamycin. | Sirolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |