Title : Platelet-activating factor production in stimulated macrophages is down-regulated by concurrently produced prostaglandin E2.

Pub. Date : 1996 Jun

PMID : 8667229






4 Functional Relationships(s)
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1 In the presence of the cyclooxygenase inhibitor indomethacin, TPA-induced PAF production was further enhanced dose-dependently in accordance with decrease of PGE2 levels. Indomethacin PCNA clamp associated factor Rattus norvegicus
2 In addition, indomethacin further enhanced PAF production that was stimulated by the protein kinase C activators, aplysiatoxin and teleocidin. Indomethacin PCNA clamp associated factor Rattus norvegicus
3 Inhibition of PAF production by exogenous arachidonic acid was abolished by indomethacin. Indomethacin PCNA clamp associated factor Rattus norvegicus
4 Furthermore, PAF production stimulated by the endomembrane Ca+2-ATPase inhibitors thapsigargin or thapsigargicin, or by the Ca+2 ionophore A23187, was also enhanced by indomethacin in compensation for the decrease in PGE2 production. Indomethacin PCNA clamp associated factor Rattus norvegicus