Title : Mutations in the B12-binding region of methionine synthase: how the protein controls methylcobalamin reactivity.

Pub. Date : 1996 Feb 20

PMID : 8652590






1 Functional Relationships(s)
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1 The lower axial ligand to the cobalt in free methylcobalamin is the dimethylbenzimidazole nucleotide substituent of the corrin ring; when methylcobalamin binds to methionine synthase, the ligand is replaced by histidine 759, which in turn is linked by hydrogen bonds to aspartate 757 and thence to serine 810. corrin 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens