Title : Endothelin-1 is involved in norepinephrine-induced ventricular hypertrophy in vivo. Acute effects of bosentan, an orally active, mixed endothelin ETA and ETB receptor antagonist.

Pub. Date : 1996 Jun 1

PMID : 8640984






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Endothelin-1 is involved in norepinephrine-induced ventricular hypertrophy in vivo. Norepinephrine endothelin 1 Rattus norvegicus
2 Ventricular expression of ET-1 mRNA was elevated in the norepinephrine group at 1, 2, and 3 days. Norepinephrine endothelin 1 Rattus norvegicus
3 CONCLUSIONS: These data suggest that endogenous ET-1 plays a direct role in mediating norepinephrine-induced ventricular hypertrophy in vivo. Norepinephrine endothelin 1 Rattus norvegicus