Pub. Date : 1996 May 24
PMID : 8637005
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inter-ring communication is disrupted in the GroEL mutant Arg13 --> Gly; Ala126 --> Val with known crystal structure. | Glycine | heat shock protein family D (Hsp60) member 1 | Homo sapiens |
| 2 | The crystal structures of the chaperonin GroEL Arg13 --> Gly; Ala126 --> Val double mutant, without and in complex with ATP gamma S, have been determined at atomic resolution. | Glycine | heat shock protein family D (Hsp60) member 1 | Homo sapiens |
| 3 | Here, we show that the double mutation Arg13 --> Gly; Ala126 --> Val disrupts negative co-operativity between GroEL rings, with respect to ATP, but has little effect on the positive co-operativity within each ring. | Glycine | heat shock protein family D (Hsp60) member 1 | Homo sapiens |