Title : Generation of DOPA-producing astrocytes by retroviral transduction of the human tyrosine hydroxylase gene: in vitro characterization and in vivo effects in the rat Parkinson model.

Pub. Date : 1996 May

PMID : 8635567






1 Functional Relationships(s)
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1 With future improvement in the gene transduction procedure for more efficient, sustained expression of the TH transgene in vivo, genetically engineered DOPA-producing astrocytes hold great promise as a tool to explore the potential of ex vivo gene therapy in Parkinson"s disease. Levodopa tyrosine hydroxylase Rattus norvegicus