Title : 4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase.

Pub. Date : 1996 Apr 30

PMID : 8633019






2 Functional Relationships(s)
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1 However, the immunosuppressant rapamycin blocks serum-induced 4E-BP1 phosphorylation and, in parallel, p70s6k activation, with no apparent effect on p42mapk activation. Sirolimus ribosomal protein S6 kinase B1 Homo sapiens
2 The insulin effect on 4E-BP1 phosphorylation and p70s6k activation in both cell types is blocked by SQ20006, wortmannin, and rapamycin. Sirolimus ribosomal protein S6 kinase B1 Homo sapiens