Title : Arbutin: mechanism of its depigmenting action in human melanocyte culture.

Pub. Date : 1996 Feb

PMID : 8632348






3 Functional Relationships(s)
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1 Arbutin inhibited the tyrosinase activity of cultured human melanocytes at noncytotoxic concentrations. Arbutin tyrosinase Homo sapiens
2 The study of the kinetics and mechanism for inhibition of tyrosinase confirms the reversibility of arbutin as a competitive inhibitor of this enzyme. Arbutin tyrosinase Homo sapiens
3 The utilization of L-tyrosine or L-dopa as the substrate suggests a mechanism involving competition with arbutin for the L-tyrosine binding site at the active site of tyrosinase. Arbutin tyrosinase Homo sapiens