Title : Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine.

Pub. Date : 1996 May

PMID : 8627552






4 Functional Relationships(s)
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1 Pharmacological evaluation of novel Alzheimer"s disease therapeutics: acetylcholinesterase inhibitors related to galanthamine. Galantamine acetylcholinesterase Rattus norvegicus
2 Recently, another AChE inhibitor, galanthamine hydrobromide (GAL), has shown increased clinical efficacy and safety. Galantamine acetylcholinesterase Rattus norvegicus
3 Recently, another AChE inhibitor, galanthamine hydrobromide (GAL), has shown increased clinical efficacy and safety. Galantamine acetylcholinesterase Rattus norvegicus
4 In vitro, 6-O-demethylgalanthamine was 10- to 20-fold more potent than GAL as an inhibitor of AChE, and it demonstrated greater selectivity for inhibition of AChE vs. butyrylcholinesterase. Galantamine acetylcholinesterase Rattus norvegicus