Title : Regulation of membrane-bound phospholipase D by protein kinase C in HL60 cells. Synergistic action of small GTP-binding protein RhoA.

Pub. Date : 1996 Feb 23

PMID : 8626786






3 Functional Relationships(s)
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1 The PKC-mediated PLD activation was completely inhibited by neomycin, a high affinity ligand for PIP2, and this suppression was recovered by the addition of exogenous PIP2. Phosphatidylinositol 4,5-Diphosphate glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens
2 The PKC-mediated PLD activation was completely inhibited by neomycin, a high affinity ligand for PIP2, and this suppression was recovered by the addition of exogenous PIP2. Phosphatidylinositol 4,5-Diphosphate glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens
3 Thus, these results suggest that PIP2 is supposed to play a key role in PKC-mediated PLD activity in HL60 membranes. Phosphatidylinositol 4,5-Diphosphate glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens