Title : Anti-invasive activity of ursolic acid correlates with the reduced expression of matrix metalloproteinase-9 (MMP-9) in HT1080 human fibrosarcoma cells.

Pub. Date : 1996 May 15

PMID : 8625299






7 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Anti-invasive activity of ursolic acid correlates with the reduced expression of matrix metalloproteinase-9 (MMP-9) in HT1080 human fibrosarcoma cells. ursolic acid matrix metallopeptidase 9 Homo sapiens
2 Anti-invasive activity of ursolic acid correlates with the reduced expression of matrix metalloproteinase-9 (MMP-9) in HT1080 human fibrosarcoma cells. ursolic acid matrix metallopeptidase 9 Homo sapiens
3 Quantitative gelatin-based zymography confirmed a markedly reduced expression of MMP-9 but not MMP-2 after treatment with UA. ursolic acid matrix metallopeptidase 9 Homo sapiens
4 To confirm the UA-induced down-regulation of MMP-9 expression, we constructed a secreted alkaline phosphatase (SEAP) reporter vector including MMP-9 promoter. ursolic acid matrix metallopeptidase 9 Homo sapiens
5 To confirm the UA-induced down-regulation of MMP-9 expression, we constructed a secreted alkaline phosphatase (SEAP) reporter vector including MMP-9 promoter. ursolic acid matrix metallopeptidase 9 Homo sapiens
6 After transfection of MMP-9/SEAP reporter vector into HT1080 cells, reduced SEAP activity was detected after treatment with UA. ursolic acid matrix metallopeptidase 9 Homo sapiens
7 These results suggest that down-regulation of MMP-9 contributes to the anti-invasive activity of UA in HT1080 cells. ursolic acid matrix metallopeptidase 9 Homo sapiens