Title : Functional reconstitution of P-glycoprotein reveals an apparent near stoichiometric drug transport to ATP hydrolysis.

Pub. Date : 1996 Feb 9

PMID : 8621717






2 Functional Relationships(s)
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1 We have recently described an ATP-driven, valinomycin-dependent 86Rb+uptake into proteoliposomes reconstituted with mammalian P-glycoprotein (Eytan, G. D., Borgnia, M. J., Regev, R., and Assaraf, Y. G. (1994) J. Biol. Valinomycin ATP binding cassette subfamily B member 1 Homo sapiens
2 The amount of 86Rb+ ions transported within 1 min via the ATP- and valinomycin-dependent P-glycoprotein was equivalent to an intravesicular cation concentration of 8 mM. Valinomycin ATP binding cassette subfamily B member 1 Homo sapiens