Title : Role of nitric oxide in short-term and prolonged effects of angiotensin II on renal hemodynamics.

Pub. Date : 1996 May

PMID : 8621213






2 Functional Relationships(s)
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1 Therefore, we designed these studies to test the hypothesis that Ang II exerts time-dependent effects on renal NO generation as assessed from renal excretion of nitrate and nitrite, percent increases in renal vascular resistance during inhibition of NO synthase with intravenous NG -nitro-L-arginine methyl ester (L-NAME), or decreases in renal vascular resistance during stimulation of endothelial NO synthase with intravenous acetylcholine. Nitrites angiotensinogen Rattus norvegicus
2 The renal excretion of nitrate and nitrite was increased during short-term Ang II infusions (from 205 +/- 22 to 331 +/- 58 pmol.min-1, P < .05) but was unchanged during prolonged Ang II infusion (control group, 197 +/- 33 versus Ang II, 245 +/- 42 pmol.min-1, P=NS). Nitrites angiotensinogen Rattus norvegicus