Title : Salicylate or aspirin inhibits the induction of the inducible nitric oxide synthase in rat cardiac fibroblasts.

Pub. Date : 1996 May

PMID : 8620595






2 Functional Relationships(s)
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1 Salicylate, when given either before or after IFN + TNF, reduced mRNA levels of iNOS induced by cytokines. Salicylates nitric oxide synthase 2 Rattus norvegicus
2 These studies implicate cardiac fibroblasts as a source of NO in inflammatory cardiac diseases and suggest a possible therapeutic role for salicylate and aspirin in diminishing the steady state levels of iNOS mRNA. Salicylates nitric oxide synthase 2 Rattus norvegicus