Pub. Date : 1996 May
PMID : 8615394
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dehydroepiandrosterone reduces plasma plasminogen activator inhibitor type 1 and tissue plasminogen activator antigen in men. | Dehydroepiandrosterone | serpin family E member 1 | Homo sapiens |
| 2 | In the DHEA group, serum DHEA-sulfate (from 7.5 +/- 1.2 micromol/L to 20.2 +/- 1.5 micromol/L (P < 0.0001), androstenedione (from 2.6 +/- 0.2 nmol/L to 4.0 +/- 0.4 nmol/L; P < 0.005) and estrone (from 172 +/- 21 pmol/L to 352 +/- 28 pmol/L; P < 0.005) increased, whereas plasma PAI-1 (from 55.4 +/- 3.8 ng/mL to 38.6 +/- 3.3 ng/mL; P < 0.0001) and tPA antigen (from 8.1 +/- 1.9 ng/mL to 5.4 +/- 1.3 ng/mL; P < 0.0005) decreased. | Dehydroepiandrosterone | serpin family E member 1 | Homo sapiens |
| 3 | These findings suggest that DHEA administration reduces plasma PAI-1 and tPA antigen concentrations in men. | Dehydroepiandrosterone | serpin family E member 1 | Homo sapiens |