Pub. Date : 1996 Apr 26
PMID : 8613987
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of sodium on the energetics of thrombin-thrombomodulin interaction and its relevance for protein C hydrolysis. | Sodium | coagulation factor II, thrombin | Homo sapiens |
| 2 | Namely, at 25 degrees C, the value of delta G of sodium binding was found equal to -2.4 kcal/mol in the absence of TM and -3.6 kcal/mol for the thrombin-TM complex. | Sodium | coagulation factor II, thrombin | Homo sapiens |
| 3 | The enthalpic contribution to the free energy of sodium binding is equal to -27 kcal/mol and -21 kcal/mol in the TM-free and TM-bound thrombin forms, respectively. | Sodium | coagulation factor II, thrombin | Homo sapiens |
| 4 | Finally, the entropy change for sodium binding was also affected by TM, being equal to -83 cal/(mol deg) and -58 cal/(mol deg) in TM-free and TM-bound thrombin species, respectively. | Sodium | coagulation factor II, thrombin | Homo sapiens |
| 5 | Therefore, the effect of sodium binding to thrombin on the hydrolysis of human Protein C was extensively investigated. | Sodium | coagulation factor II, thrombin | Homo sapiens |