Title : Integrin alpha 4 cysteines 278 and 717 modulate VLA-4 ligand binding and also contribute to alpha 4/180 formation.

Pub. Date : 1996 Feb 1

PMID : 8611173






4 Functional Relationships(s)
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Compound Name
Protein Name
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1 Integrin alpha 4 cysteines 278 and 717 modulate VLA-4 ligand binding and also contribute to alpha 4/180 formation. Cysteine integrin subunit alpha 4 Homo sapiens
2 Here we describe experiments in which we mutated four of the six integrin alpha 4 subunit cysteine residues that are not present in most other integrin alpha subunits that lack an I domain. Cysteine integrin subunit alpha 4 Homo sapiens
3 In four different types of ligand binding assay we found that optimal integrin alpha 4 beta 1 and/or to CS1 peptide required the presence of both alpha 4 Cys 278 and Cys 717. Cysteine integrin subunit alpha 4 Homo sapiens
4 In four different types of ligand binding assay we found that optimal integrin alpha 4 beta 1 and/or to CS1 peptide required the presence of both alpha 4 Cys 278 and Cys 717. Cysteine integrin subunit alpha 4 Homo sapiens