Pub. Date : 1996 Apr 2
PMID : 8610122
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To determine inhalational anesthetic binding domains on a ligand-gated ion channel, I used halothane direct photoaffinity labeling of the nicotinic acetylcholine receptor (nAChR) in native Torpedo membranes. | Halothane | cholinergic receptor nicotinic alpha 4 subunit | Homo sapiens |
| 2 | To determine inhalational anesthetic binding domains on a ligand-gated ion channel, I used halothane direct photoaffinity labeling of the nicotinic acetylcholine receptor (nAChR) in native Torpedo membranes. | Halothane | cholinergic receptor nicotinic alpha 4 subunit | Homo sapiens |
| 3 | [14C]Halothane photoaffinity labeling of both the native Torpedo membranes and the isolated nAChR was saturable, with Kd values within the clinically relevant range. | Halothane | cholinergic receptor nicotinic alpha 4 subunit | Homo sapiens |
| 4 | Unlabeled halothane reduced labeling more than did isoflurane, suggesting differences in the binding domains for inhalational anesthetics in the nAChR. | Halothane | cholinergic receptor nicotinic alpha 4 subunit | Homo sapiens |
| 5 | These data suggest multiple similar binding domains for halothane in the transmembrane region of the nAChR. | Halothane | cholinergic receptor nicotinic alpha 4 subunit | Homo sapiens |