Title : Stimulation of endometrial cancer cell growth by tamoxifen is associated with increased insulin-like growth factor (IGF)-I induced tyrosine phosphorylation and reduction in IGF binding proteins.

Pub. Date : 1996 Mar

PMID : 8603578






3 Functional Relationships(s)
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1 The purpose of the present study was to examine the involvement of the IGF system in the tamoxifen-stimulated growth of Ishikawa endometrial cancer cells by quantitating the IGF-I receptors and their phosphorylation, as well as membrane associated and secreted IGF-binding proteins (IGFBPs). Tamoxifen insulin like growth factor binding protein 3 Homo sapiens
2 Tamoxifen caused a 3-fold decrease in membrane-associated IGFBPs. Tamoxifen insulin like growth factor binding protein 3 Homo sapiens
3 Furthermore, the decrease in IGFBPs and the increase in tyrosine phosphorylation in the presence of tamoxifen provides a molecular mechanism that accounts for the uterotropic effects that are seen with tamoxifen therapy. Tamoxifen insulin like growth factor binding protein 3 Homo sapiens