Title : Serotonin depletion decreases serotonin transporter mRNA levels in rat brain.

Pub. Date : 1995 Oct 30

PMID : 8593584






2 Functional Relationships(s)
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1 In order to study the impact of serotonin depletion on gene expression of the serotonin transporter (5-HTt) we measured 5-HTt mRNA levels by Northern blot in rats treated with p-chlorophenylalanine methyl ester (PCPA) for 10 days. Fenclonine solute carrier family 6 member 4 Rattus norvegicus
2 5-HTt mRNA levels decreased to 81.1% (P = 0.05) and 76.0% (P = 0.05) of the control level for PCPA treated animals without and with concomitant imipramine treatment, respectively. Fenclonine solute carrier family 6 member 4 Rattus norvegicus