Title : Effects of extracellular calcium on insulin-like growth factor II in human bone cells.

Pub. Date : 1995 Nov

PMID : 8592942






5 Functional Relationships(s)
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1 The effects of an increase in extracellular calcium by 1 mM were: 1) increased culture media levels of IGF-II within 1 h of treatment, 2) the increase in IGF-II levels reached a maximum after 8 h of treatment, and 3) IGF-II levels were still elevated after 24 h of treatment. Calcium insulin like growth factor 2 Homo sapiens
2 The effects of an increase in extracellular calcium by 1 mM were: 1) increased culture media levels of IGF-II within 1 h of treatment, 2) the increase in IGF-II levels reached a maximum after 8 h of treatment, and 3) IGF-II levels were still elevated after 24 h of treatment. Calcium insulin like growth factor 2 Homo sapiens
3 The effects of an increase in extracellular calcium by 1 mM were: 1) increased culture media levels of IGF-II within 1 h of treatment, 2) the increase in IGF-II levels reached a maximum after 8 h of treatment, and 3) IGF-II levels were still elevated after 24 h of treatment. Calcium insulin like growth factor 2 Homo sapiens
4 Furthermore, a blocking monoclonal antibody against IGF-II abolished the increased cell proliferation in HBV155 cells following elevation of extracellular calcium. Calcium insulin like growth factor 2 Homo sapiens
5 Taken together, these findings suggest that an increase in extracellular calcium results in an increase in IGF-II which is required for the subsequent increase in cell proliferation. Calcium insulin like growth factor 2 Homo sapiens