Title : Method for screening drug and chemical effects in laboratory rats using computerized quantitative electroencephalography.

Pub. Date : 1995 Dec

PMID : 8588286






1 Functional Relationships(s)
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1 For this study, physostigmine was administered ip at doses of 0.05, 0.2 or 1.0 mg/kg, resulting in average cholinesterase inhibition in plasma (28, 38 and 70%), erythrocytes (19, 24 and 36%), and brain (2, 10 and 31%) which correlated well with increased total power and amplitude changes. Physostigmine butyrylcholinesterase Rattus norvegicus