Pub. Date : 1995 Oct 20
PMID : 8584752
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A decrease in angiotensin receptor binding in rat brain nuclei by antisense oligonucleotides to the angiotensin AT1 receptor. | Oligonucleotides | angiotensin II receptor, type 1a | Rattus norvegicus |
| 2 | injections of antisense oligonucleotides against mRNA of the angiotensin type 1 (AT1) receptor have been shown to reduce blood pressure in spontaneously hypertensive (SHR) rats and angiotensin II-induced drinking in both SHR and Sprague-Dawley (SD) rats. | Oligonucleotides | angiotensin II receptor, type 1a | Rattus norvegicus |
| 3 | injections of antisense oligonucleotides to the AT1 receptor mRNA on brain angiotensin receptors using membrane binding and autoradiographic analysis. | Oligonucleotides | angiotensin II receptor, type 1a | Rattus norvegicus |
| 4 | Three daily injections of antisense oligonucleotides into the third ventricle of SD rats decreased the AT1 receptor number significantly by 25% in a hypothalamic tissue block. | Oligonucleotides | angiotensin II receptor, type 1a | Rattus norvegicus |
| 5 | AT2 receptors were not reduced indicating the AT1 antisense oligonucleotides were specific. | Oligonucleotides | angiotensin II receptor, type 1a | Rattus norvegicus |
| 6 | injections of antisense oligonucleotides to AT1 receptor mRNA. | Oligonucleotides | angiotensin II receptor, type 1a | Rattus norvegicus |