Title : EJ-Ras inhibits phospholipase C gamma 1 but not actin polymerization induced by platelet-derived growth factor-BB via phosphatidylinositol 3-kinase.

Pub. Date : 1996 Feb

PMID : 8575075






1 Functional Relationships(s)
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1 Transformation of fibroblast-like cells (NIH 3T3) by a constitutively activated GTP-bound isoform of p21ras (EJ-Ras) produces morphogenic changes characterized by decreased attachment to the substratum, with retraction and rounding of the cell body. Guanosine Triphosphate Harvey rat sarcoma virus oncogene Mus musculus