Title : Characterization of 5-hydroxytryptamine1A properties of flesinoxan: in vivo electrophysiology and hypothermia study.

Pub. Date : 1995 Oct

PMID : 8570029






4 Functional Relationships(s)
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1 The suppressant effect of microiontophoretic applications of flesinoxan on the firing activity of CA3 pyramidal neurons was blocked by concomitant application of the 5-HT1A antagonist BMY 7378. flesinoxan carbonic anhydrase 3 Rattus norvegicus
2 Compared to gepirone, the efficacy of flesinoxan to suppress the firing activity of CA3 pyramidal neurons was significantly greater. flesinoxan carbonic anhydrase 3 Rattus norvegicus
3 The capacity of flesinoxan to antagonize the effect of 5-HT on CA3 pyramidal neurons was similar to that of 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) and significantly greater than that of gepirone. flesinoxan carbonic anhydrase 3 Rattus norvegicus
4 The intravenous administration of flesinoxan suppressed the firing activity of both CA3 pyramidal neurons and dorsal raphe 5-HT neurons. flesinoxan carbonic anhydrase 3 Rattus norvegicus