Pub. Date : 1995 Oct 1
PMID : 8568921
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effects of a series of protein kinase inhibitors on nerve growth factor (NGF)-dependent and NGF-independent neurite outgrowth in PC12 cells have established an ordered relationship among those protein kinases sensitive to down regulation by bryostatin, stimulation by staurosporine, inhibition by sphingosine, or inhibition by 6-thioguanine (6-TG). | Staurosporine | nerve growth factor | Rattus norvegicus |
| 2 | The effects of a series of protein kinase inhibitors on nerve growth factor (NGF)-dependent and NGF-independent neurite outgrowth in PC12 cells have established an ordered relationship among those protein kinases sensitive to down regulation by bryostatin, stimulation by staurosporine, inhibition by sphingosine, or inhibition by 6-thioguanine (6-TG). | Staurosporine | nerve growth factor | Rattus norvegicus |
| 3 | Quantitation of the biphasic staurosporine effects on NGF-induced neurite outgrowth (Hashimoto and Hagino: J Neurochem 53:1675-1685, 1989) gave an IC50 of 2-4 nM for inhibition and an EC50 of 15-20 nM for induction of neurite extension. | Staurosporine | nerve growth factor | Rattus norvegicus |
| 4 | Inhibition by 5-7.5 nM staurosporine acted rapidly to arrest and decrease development of neurites up to 24 hr after NGF treatment, as did K252a and NGF polyclonal antibody addition. | Staurosporine | nerve growth factor | Rattus norvegicus |
| 5 | Our cellular data support the concept that staurosporine acts to inhibit the NGF receptor Trk (Nye et al. | Staurosporine | nerve growth factor | Rattus norvegicus |