Protein Name nerve growth factor
Organism Rattus norvegicus
Gene ID 310738
Gene Symbol


UniProt P25427 (NGF_RAT)
Relationships Total Number of functionally related compound(s) : 1122
Total Number of Articles : 1694

nerve growth factor

Gene Summary

Predicted to enable nerve growth factor receptor binding activity; peptidase regulator activity; and signaling receptor activator activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; and response to ozone. Acts upstream of or within positive regulation of DNA-binding transcription factor activity; positive regulation of neurotrophin TRK receptor signaling pathway; and positive regulation of protein autophosphorylation. Located in extracellular space. Used to study bladder neck obstruction; cystitis; degenerative disc disease; and neurogenic bladder. Biomarker of several diseases, including diabetic neuropathy; hyperhomocysteinemia; mental depression; myofascial pain syndrome; and respiratory syncytial virus infectious disease. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; asthma; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; and interstitial cystitis. Orthologous to human NGF (nerve growth factor). [provided by Alliance of Genome Resources, Apr 2022]

  • beta-nerve growth factor
  • nerve growth factor (beta polypeptide)
  • pro-nerve growth factor long
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