| Protein Name | nerve growth factor |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 310738 |
| Gene Symbol | Ngf |
| UniProt | P25427 (NGF_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
1122
Total Number of Articles : 1694 |
Description |
nerve growth factor |
| Gene Summary |
Predicted to enable nerve growth factor receptor binding activity; peptidase regulator activity; and signaling receptor activator activity. Involved in several processes, including negative regulation of apoptotic process; nervous system development; and positive regulation of ERK1 and ERK2 cascade. Acts upstream of or within positive regulation of DNA-binding transcription factor activity; positive regulation of neurotrophin TRK receptor signaling pathway; and positive regulation of protein autophosphorylation. Located in extracellular space. Used to study several diseases, including bladder neck obstruction; bone disease (multiple); middle cerebral artery infarction; neurogenic bladder; and overactive bladder syndrome. Biomarker of several diseases, including alcohol dependence; alcohol use disorder; borna disease; cryptorchidism; and hyperhomocysteinemia. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; interstitial cystitis; and opiate dependence (multiple). Orthologous to human NGF (nerve growth factor). [provided by Alliance of Genome Resources, Jun 2025] |
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