Pub. Date : 1996 Jan 9
PMID : 8552605
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Bone marrow CNU sensitivity is probably due to the inefficient repair of CNU-induced DNA damage; relative to other tissues, bone marrow cells express extremely low levels of the O6-methylguanine DNA methyltransferase (MGMT) protein that repairs cytotoxic O6-chloroethylguanine DNA lesions. | 1-(2-chloroethyl)-1-nitrosourea | O-6-methylguanine-DNA methyltransferase | Mus musculus |
2 | Bone marrow CNU sensitivity is probably due to the inefficient repair of CNU-induced DNA damage; relative to other tissues, bone marrow cells express extremely low levels of the O6-methylguanine DNA methyltransferase (MGMT) protein that repairs cytotoxic O6-chloroethylguanine DNA lesions. | 1-(2-chloroethyl)-1-nitrosourea | O-6-methylguanine-DNA methyltransferase | Mus musculus |
3 | Stable reconstitution of mouse bone marrow with genetically modified, MGMT-expressing hematopoietic stem cells conferred considerable resistance to the cytotoxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), a CNU commonly used for chemotherapy. | 1-(2-chloroethyl)-1-nitrosourea | O-6-methylguanine-DNA methyltransferase | Mus musculus |