Title : Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent.

Pub. Date : 1996 Jan 9

PMID : 8552605






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Bone marrow CNU sensitivity is probably due to the inefficient repair of CNU-induced DNA damage; relative to other tissues, bone marrow cells express extremely low levels of the O6-methylguanine DNA methyltransferase (MGMT) protein that repairs cytotoxic O6-chloroethylguanine DNA lesions. 1-(2-chloroethyl)-1-nitrosourea O-6-methylguanine-DNA methyltransferase Mus musculus
2 Bone marrow CNU sensitivity is probably due to the inefficient repair of CNU-induced DNA damage; relative to other tissues, bone marrow cells express extremely low levels of the O6-methylguanine DNA methyltransferase (MGMT) protein that repairs cytotoxic O6-chloroethylguanine DNA lesions. 1-(2-chloroethyl)-1-nitrosourea O-6-methylguanine-DNA methyltransferase Mus musculus
3 Stable reconstitution of mouse bone marrow with genetically modified, MGMT-expressing hematopoietic stem cells conferred considerable resistance to the cytotoxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), a CNU commonly used for chemotherapy. 1-(2-chloroethyl)-1-nitrosourea O-6-methylguanine-DNA methyltransferase Mus musculus