Title : Pituitary adenylate-cyclase activating peptide enhances aldosterone secretion of human adrenal gland: evidence for an indirect mechanism, probably involving the local release of catecholamines.

Pub. Date : 1996 Jan

PMID : 8550747






3 Functional Relationships(s)
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1 Pituitary adenylate-cyclase activating peptide enhances aldosterone secretion of human adrenal gland: evidence for an indirect mechanism, probably involving the local release of catecholamines. Catecholamines adenylate cyclase activating polypeptide 1 Homo sapiens
2 PACAP (10 nmol/L) induced a net rise in catecholamine release by adrenal slices. Catecholamines adenylate cyclase activating polypeptide 1 Homo sapiens
3 Taken together, our present findings suggest that PACAP indirectly stimulates ALDO secretion by the human adrenal cortex, probably by eliciting the local release of catecholamines by medullary chromaffin cells that are also scattered in the cortical tissue, especially the zona glomerulosa. Catecholamines adenylate cyclase activating polypeptide 1 Homo sapiens