Title : Tumor necrosis factor-alpha and interferon-gamma inhibit insulin secretion and cause DNA damage in unweaned-rat islets. Extent of nitric oxide involvement.

Pub. Date : 1996 Feb

PMID : 8549863






1 Functional Relationships(s)
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1 Use of arginine-free medium, without or with NG-monomethyl-L-arginine, resulted in inhibition of nitrite formation by 5-1,000 U/ml IFN+TNF and partial restoration of the insulin secretory response to glucose. Nitrites tumor necrosis factor Rattus norvegicus