Pub. Date : 1995 Aug 15
PMID : 8547445
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Prolactin response to buspirone challenge in the presence of dopaminergic blockade. | Buspirone | prolactin | Homo sapiens |
| 2 | Buspirone-stimulated prolactin release has been employed as an indirect measure of central serotonin activity; however, it is not clear whether serotonergic or dopaminergic systems are responsible for this response. | Buspirone | prolactin | Homo sapiens |
| 3 | In an attempt to further elucidate the mechanism, we studied the prolactin response to buspirone in eight subjects in the presence of maximal dopaminergic receptor blockade with metoclopramide under placebo-controlled, double-blind conditions. | Buspirone | prolactin | Homo sapiens |
| 4 | The prolactin response to buspirone in the presence of metoclopramide was not statistically different from that to placebo under the same conditions. | Buspirone | prolactin | Homo sapiens |
| 5 | These results lend further support to a dopaminergic mechanism in buspirone-induced prolactin secretion; therefore, further caution is warranted in interpreting the results of this challenge test as a measure of serotonergic activity in the brain. | Buspirone | prolactin | Homo sapiens |