PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8547445-0 1995 Prolactin response to buspirone challenge in the presence of dopaminergic blockade. Buspirone 22-31 prolactin Homo sapiens 0-9 8547445-1 1995 Buspirone-stimulated prolactin release has been employed as an indirect measure of central serotonin activity; however, it is not clear whether serotonergic or dopaminergic systems are responsible for this response. Buspirone 0-9 prolactin Homo sapiens 21-30 8547445-2 1995 In an attempt to further elucidate the mechanism, we studied the prolactin response to buspirone in eight subjects in the presence of maximal dopaminergic receptor blockade with metoclopramide under placebo-controlled, double-blind conditions. Buspirone 87-96 prolactin Homo sapiens 65-74 8547445-3 1995 The prolactin response to buspirone in the presence of metoclopramide was not statistically different from that to placebo under the same conditions. Buspirone 26-35 prolactin Homo sapiens 4-13 8547445-5 1995 These results lend further support to a dopaminergic mechanism in buspirone-induced prolactin secretion; therefore, further caution is warranted in interpreting the results of this challenge test as a measure of serotonergic activity in the brain. Buspirone 66-75 prolactin Homo sapiens 84-93