Title : Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver.

Pub. Date : 1996 Jan 12

PMID : 8534266






6 Functional Relationships(s)
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1 Curcumin was also a potent inhibitor of glutathione S-transferase (GST) activity in cytosol from liver of rats treated with phenobarbital (PB), beta-naphthoflavone (beta NF) and pyrazole (Pyr), when measured towards 1-chloro-2,4-dinitrobenzene (CDNB) as substrate. Phenobarbital hematopoietic prostaglandin D synthase Rattus norvegicus
2 Curcumin was also a potent inhibitor of glutathione S-transferase (GST) activity in cytosol from liver of rats treated with phenobarbital (PB), beta-naphthoflavone (beta NF) and pyrazole (Pyr), when measured towards 1-chloro-2,4-dinitrobenzene (CDNB) as substrate. Phenobarbital hematopoietic prostaglandin D synthase Rattus norvegicus
3 Curcumin was also a potent inhibitor of glutathione S-transferase (GST) activity in cytosol from liver of rats treated with phenobarbital (PB), beta-naphthoflavone (beta NF) and pyrazole (Pyr), when measured towards 1-chloro-2,4-dinitrobenzene (CDNB) as substrate. Phenobarbital hematopoietic prostaglandin D synthase Rattus norvegicus
4 Curcumin was also a potent inhibitor of glutathione S-transferase (GST) activity in cytosol from liver of rats treated with phenobarbital (PB), beta-naphthoflavone (beta NF) and pyrazole (Pyr), when measured towards 1-chloro-2,4-dinitrobenzene (CDNB) as substrate. Phenobarbital hematopoietic prostaglandin D synthase Rattus norvegicus
5 In liver cytosol from rats treated with phenobarbital (PB), curcumin inhibited GST activity in a mixed-type manner with a Ki of 5.75 microM and Ki of 12.5 microM. Phenobarbital hematopoietic prostaglandin D synthase Rattus norvegicus
6 In liver cytosol from rats treated with phenobarbital (PB), curcumin inhibited GST activity in a mixed-type manner with a Ki of 5.75 microM and Ki of 12.5 microM. Phenobarbital hematopoietic prostaglandin D synthase Rattus norvegicus