Pub. Date : 1995 Sep
PMID : 8523447
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cardiac troponin C as a target protein for a novel calcium sensitizing drug, levosimendan. | Simendan | troponin C1, slow skeletal and cardiac type | Homo sapiens |
| 2 | The role of cardiac troponin C (cTnC) as a target protein for the calcium sensitization by levosimendan, pimobendan, MCI-154 and EMD 53998 was evaluated using purified recombinant human cTnC. | Simendan | troponin C1, slow skeletal and cardiac type | Homo sapiens |
| 3 | The role of cardiac troponin C (cTnC) as a target protein for the calcium sensitization by levosimendan, pimobendan, MCI-154 and EMD 53998 was evaluated using purified recombinant human cTnC. | Simendan | troponin C1, slow skeletal and cardiac type | Homo sapiens |
| 4 | Only levosimendan showed calcium-dependent and to a lesser extent magnesium-dependent retention in the cTnC column. | Simendan | troponin C1, slow skeletal and cardiac type | Homo sapiens |
| 5 | The findings indicate that levosimendan binds both to the N-terminal and C-terminal domains of cTnC. | Simendan | troponin C1, slow skeletal and cardiac type | Homo sapiens |
| 6 | In agreement with this, only levosimendan shifted the calcium-induced fluorescence curve of dansylated cTnC to the left. | Simendan | troponin C1, slow skeletal and cardiac type | Homo sapiens |
| 7 | In conclusion, it is suggested that the mechanism of calcium sensitizing effect of levosimendan, unlike that of the other calcium sensitizers, is based on calcium-dependent binding to the N-terminal domain of cTnC. | Simendan | troponin C1, slow skeletal and cardiac type | Homo sapiens |