Pub. Date : 1993 Apr
PMID : 8518837
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Furthermore, CYP2C9 produced by cDNA expression in yeasts, catalysed tolbutamide hydroxylation at rates similar to the rapid metabolizer group at both the 0.1 mM and 2.4 mM concentrations. | Tolbutamide | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 2 | Clear correlations were observed between the rate of microsomal tolbutamide hydroxylation at 0.1 mM and CYP2C9 protein content or the rate of S-mephenytoin 4"-hydroxylation in human liver. | Tolbutamide | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 3 | These results indicate that considerable portions of microsomal tolbutamide hydroxylation are catalysed by CYP2C9 or the closely related form in the rapid metabolizers. | Tolbutamide | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |