Title : Growth inhibition of ovarian cancer cells induced by antisense IL-6 oligonucleotides.

Pub. Date : 1993 Apr

PMID : 8482564






1 Functional Relationships(s)
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1 Exposure of ovarian cancer cell lines (CAOV-3, OVCAR-3, and OC-436), to 1-5 microM of a 15-base single-stranded antisense IL-6 oligodeoxynucleotide, specific for a sequence in the second coding exon of the IL-6 gene, resulted in decreased IL-6 production and a > 80-85% inhibition of cellular proliferation. Oligodeoxyribonucleotides interleukin 6 Homo sapiens